blood-brain barrier antidepressant amitriptyline
Normally, P-glycoprotein prevents most medicines from entering the brain by pumping them back into the blood stream (left). The addition of amitriptyline temporarily turns off P-glycoprotein pumps, allowing drug molecules to cross the blood-brain barrier (right). NIEHS
Health and Fitness, Science

Antidepressant May Enhance Drug Delivery To The Brain

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blood-brain barrier antidepressant amitriptyline
Normally, P-glycoprotein prevents most medicines from entering the brain by pumping them back into the blood stream (left). The addition of amitriptyline temporarily turns off P-glycoprotein pumps, allowing drug molecules to cross the blood-brain barrier (right). NIEHS

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