Health and Fitness Newly Identified Molecular Mechanism Plays Role in Obesity-related Type 2 Diabetes Development by Gary Kopycinski on July 31, 2015 Gary Kopycinski Author More in Health and Fitness: On Hantavirus, Park Forest Officials Urge Caution May 18, 2026 Rep. Kelly Condemns FDA Approval of Flavored E-Cigarettes May 6, 2026 Park Forest Aligns With Illinois Guidance on Childhood Vaccines Amid Federal Changes January 11, 2026 Depiction of nitrosylated IRE1 on the ER membrane. The red-blue molecules are NO; yellow represents the nitrosylated cysteines of IRE1.