Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Bethesda, Maryland–(ENEWSPF)–May 26, 2016. Scientists using a technology called cryo-EM (cryo-electron microscopy) have broken through a technological barrier in visualizing proteins with an approach that may have an impact on drug discovery and development. They were able to capture images of glutamate dehydrogenase, an enzyme found in cells, at a resolution of 1.8 angstroms, a level of detail at which the structure…
